Description

n-Boc-3A,4,7,7A-Tetrahydroisoindole is a protected isoindoline derivative, serving as a versatile and high-purity pharmaceutical intermediate and building block in advanced organic synthesis. Its core value lies in providing a reactive nitrogen center shielded by the acid-labile tert-butoxycarbonyl (Boc) protecting group, enabling precise synthetic manipulation. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, particularly those containing isoindoline or tetrahydroisoquinoline scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides requiring specific heterocyclic frameworks.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex molecules, leveraging the reactivity of the deprotected secondary amine.
• Material Science Research: Potential precursor for the development of specialty chemicals and functional materials with specific optical or electronic properties.

Basic Information

Product Name	n-Boc-3A,4,7,7A-Tetrahydroisoindole
CAS No.	474925-37-6
Molecular Formula	C₁₃H₂₁NO₂
Molecular Weight	223.31 g/mol
Synonyms	1,1-Dimethylethyl 3a,4,7,7a-tetrahydro-1H-isoindole-2(3H)-carboxylate; tert-Butyl 3a,4,7,7a-tetrahydroisoindole-2(3H)-carboxylate; Boc-3a,4,7,7a-tetrahydroisoindole; N-Boc-3a,4,7,7a-tetrahydroisoindoline; 2-(tert-Butoxycarbonyl)-3a,4,7,7a-tetrahydroisoindole; 3a,4,7,7a-Tetrahydroisoindole-2-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-3A,4,7,7A-Tetrahydroisoindole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product may be hygroscopic; keep the container tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.