Description

Cyclopropanemethanol, 2-Bromo-2-Methyl-, (1R,2R)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its core value lies in its rigid cyclopropane ring and bromine functionality, which enable precise stereocontrol and the introduction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, where its defined stereochemistry is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the cyclopropane moiety can enhance metabolic stability and target specificity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to produce enantiomerically pure compounds.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers with unique mechanical or optical properties derived from the strained cyclopropane ring.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme mechanisms and biological pathways due to its ability to act as a mechanism-based inhibitor or label.

Basic Information

Product Name	Cyclopropanemethanol, 2-Bromo-2-Methyl-, (1R,2R)-Rel- (9Ci)
CAS No.	473994-83-1
Molecular Formula	C5H9BrO
Molecular Weight	165.03 g/mol
Synonyms	(1R,2R)-2-Bromo-2-methylcyclopropanemethanol; rel-(1R,2R)-2-Bromo-2-methylcyclopropanemethanol; 2-Bromo-2-methylcyclopropanemethanol, (1R,2R)-rel-; (1R,2R)-rel-2-Bromo-2-methylcyclopropanemethanol; Cyclopropanemethanol, 2-bromo-2-methyl-, (1R,2R)-rel-; (1R,2R)-2-Bromo-2-methyl-cyclopropanemethanol
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Every lot is characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with each shipment, supporting cGMP and ISO 9001 compliant workflows for our global partners in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (1R,2R)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.