Description

Bicyclo[3.1.0]Hexane-2-Acetic Acid, 2-(Aminomethyl)-6,6-Dimethyl-, (1S,2R,5R)- (9Ci) is a high-purity, stereochemically defined bicyclic amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique constrained structure and functional groups make it invaluable for constructing complex molecular architectures with precise three-dimensional control. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for applications in medicinal chemistry, including the development of novel active pharmaceutical ingredients (APIs) and peptide mimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Peptidomimetic Scaffold: Used to design and synthesize constrained peptide analogs to enhance metabolic stability and receptor selectivity.
• Agrochemical Synthesis: Employed in the development of advanced, stereospecific pesticides and herbicides.
• Ligand for Catalysis: Serves as a precursor for chiral ligands used in asymmetric synthesis and catalysis.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic chemistry and the exploration of new chemical space.
• Bioconjugation Chemistry: The amino and carboxylic acid functionalities allow for its use in linker chemistry and bioconjugate development.

Basic Information

Product Name	Bicyclo[3.1.0]Hexane-2-Acetic Acid, 2-(Aminomethyl)-6,6-Dimethyl-, (1S,2R,5R)- (9Ci)
CAS No.	473829-51-5
Molecular Formula	C11H19NO2
Molecular Weight	197.27 g/mol
Synonyms	(1S,2R,5R)-2-(Aminomethyl)-6,6-dimethylbicyclo[3.1.0]hexane-2-acetic acid; (1S,2R,5R)-2-(Aminomethyl)-6,6-dimethylbicyclo[3.1.0]hexan-2-ylacetic acid; Rel-(1S,2R,5R)-Bicyclo[3.1.0]hexane-2-acetic acid, 2-(aminomethyl)-6,6-dimethyl-; Bicyclo[3.1.0]hexane-2-acetic acid, 2-(aminomethyl)-6,6-dimethyl-, (1S,2R,5R)-; CAS 473829-51-5
EINECS	Contact for details

Quality Control

Every batch of Bicyclo[3.1.0]Hexane-2-Acetic Acid, 2-(Aminomethyl)-6,6-Dimethyl-, (1S,2R,5R)- (9Ci) is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and stereochemical integrity. We provide Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Our quality standards are designed to meet the rigorous demands of pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.