Description

(R)-Cyclopropyl(Thiophen-2-Yl)Methanamine is a high-purity chiral amine building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and other fine chemicals, where its specific stereochemistry is crucial for biological activity. It is primarily needed by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate a cyclopropyl-thiophene motif into novel molecular architectures.

Application

• As a critical chiral intermediate in the research and synthesis of novel pharmaceutical candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Utilized in the development of agrochemicals, such as herbicides and fungicides, where the stereochemistry can influence efficacy and environmental profile.
• Serves as a versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Used in asymmetric synthesis to introduce the (R)-configured aminomethyl group into complex molecular frameworks.
• Applicable in the preparation of ligands for catalysis or as a precursor for advanced materials with specific electronic properties derived from the thiophene moiety.

Basic Information

Product Name	(R)-Cyclopropyl(Thiophen-2-Yl)Methanamine
CAS No.	473733-07-2
Molecular Formula	C8H11NS
Molecular Weight	153.24 g/mol
Synonyms	(R)-1-Cyclopropyl-1-(thiophen-2-yl)methanamine; (R)-α-Cyclopropyl-2-thiophenemethylamine; (R)-2-Thienyl(cyclopropyl)methylamine; (R)-Cyclopropyl(thiophen-2-yl)methylamine; (R)-Aminomethyl(cyclopropyl)thiophene; (R)-CPTA; (R)-C-TA; (1R)-1-Cyclopropyl-1-(2-thienyl)methanamine
EINECS	Contact for details

Quality Control

Our (R)-Cyclopropyl(Thiophen-2-Yl)Methanamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation upon prolonged exposure to air.

Specification

Item	Specification
Appearance	White to off-white solid or clear to pale yellow liquid/oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.