Description

4-Fluoro-1H-Indazole-5-Carbonitrile is a high-purity fluorinated indazole derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its unique molecular scaffold, which is essential for constructing novel bioactive compounds in modern drug discovery. This product is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors, oncology therapeutics, and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of targeted cancer therapies and kinase inhibitors.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides with fluorinated active ingredients.
• Material Science: Acts as a precursor for specialty polymers and advanced organic electronic materials.
• Chemical Biology: Employed as a molecular probe or tag in proteomics and bio-conjugation studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations for custom synthesis and process development projects.
• Academic Research: Utilized in university and institutional labs for heterocyclic chemistry and medicinal chemistry research.

Basic Information

Product Name	4-Fluoro-1H-Indazole-5-Carbonitrile
CAS No.	473416-81-8
Molecular Formula	C8H4FN3
Molecular Weight	161.14 g/mol
Synonyms	4-Fluoro-1H-indazole-5-carbonitrile; 5-Cyano-4-fluoro-1H-indazole; 4-Fluoro-5-cyano-1H-indazole; 1H-Indazole-5-carbonitrile, 4-fluoro-; 473416-81-8; 4-Fluoroindazole-5-carbonitrile; 4-F-1H-Indazole-5-CN
EINECS	Contact for details

Quality Control

Our 4-Fluoro-1H-Indazole-5-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with every shipment to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.