Description

Ethyl 5-Chloro-6-Fluoro-1H-Indole-2-Carboxylate is a high-purity, multi-functional indole derivative serving as a critical building block in advanced organic synthesis. Its value lies in its precise halogenated structure, which is essential for constructing complex molecules with targeted biological activity. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of new active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncological pathways.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging its halogenated indole core.
• Material Science Research: Serves as a monomer or functional unit in the development of specialty polymers and organic electronic materials.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in heterocyclic and medicinal chemistry.
• Fluorescent Probe Development: Its indole scaffold can be utilized to create novel fluorescent markers and sensors for biochemical assays.

Basic Information

Product Name	Ethyl 5-Chloro-6-Fluoro-1H-Indole-2-Carboxylate
CAS No.	473257-60-2
Molecular Formula	C11H9ClFNO2
Molecular Weight	241.65 g/mol
Synonyms	5-Chloro-6-fluoro-1H-indole-2-carboxylic acid ethyl ester; Ethyl 5-chloro-6-fluoroindole-2-carboxylate; 2-Carbethoxy-5-chloro-6-fluoroindole; 1H-Indole-2-carboxylic acid, 5-chloro-6-fluoro-, ethyl ester; 473257-60-2; 5-Chloro-6-fluoroindole-2-carboxylic acid ethyl ester; Ethyl (5-chloro-6-fluoro-1H-indol-2-yl)carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 5-Chloro-6-Fluoro-1H-Indole-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.