Description

Silacyclopentane-3-Carboxylic Acid, 4-Amino-1,1-Dimethyl-, Ethyl Ester, (3R,4S)-Rel- (9Ci) is a high-value, stereochemically defined organosilicon building block. This compound matters for its role as a key chiral intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to incorporate unique silacyclopentane scaffolds into new active compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides where the silacyclopentane moiety can influence bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty silicon-containing polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized as a building block for creating labeled compounds and molecular probes to study biological systems.
• Process Chemistry: Investigated for scale-up in the commercial production pathway of target molecules requiring this specific stereochemistry.

Basic Information

Product Name	Silacyclopentane-3-Carboxylic Acid, 4-Amino-1,1-Dimethyl-, Ethyl Ester, (3R,4S)-Rel- (9Ci)
CAS No.	472966-15-7
Molecular Formula	C10H21NO2Si
Molecular Weight	215.37 g/mol
Synonyms	rel-(3R,4S)-4-Amino-1,1-dimethylsilacyclopentane-3-carboxylic acid ethyl ester; Ethyl 4-amino-1,1-dimethylsilacyclopentane-3-carboxylate, (3R,4S)-rel-; 1,1-Dimethyl-4-amino-silacyclopentane-3-carboxylic acid ethyl ester; Silacyclopentane-3-carboxylic acid, 4-amino-1,1-dimethyl-, ethyl ester, (3R,4S)-rel-; (rel-3R,4S)-Ethyl 4-amino-1,1-dimethylsilacyclopentane-3-carboxylate; Amino-dimethylsilacyclopentane carboxylate ethyl ester; CAS 472966-15-7
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity (typically >97% by HPLC), chiral purity, and impurity profiles to support your regulatory and R&D documentation. Our commitment to consistent quality and traceability ensures reliable performance in your critical synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. For long-term storage, keep desiccated at -20°C. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.