Description

5-(Trifluoromethyl)-1H-Indole-3-Carboxaldehyde is a versatile indole-based building block characterized by its reactive aldehyde and electron-withdrawing trifluoromethyl group. This compound is essential for the synthesis of complex molecules, particularly in the development of pharmaceuticals and agrochemicals, where the trifluoromethyl moiety is prized for enhancing metabolic stability and bioavailability. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel heterocyclic compounds and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, especially kinase inhibitors, receptor antagonists, and other biologically active molecules targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group to improve lipophilicity and biological activity.
• Material Science Research: Serves as a building block for creating organic semiconductors, fluorescent dyes, and photoactive materials due to its conjugated indole core.
• Chemical Biology & Proteomics: Employed in the design of molecular probes, enzyme inhibitors, and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and the exploration of new synthetic pathways in organic chemistry.
• Custom Synthesis & Scale-up: A critical starting material for custom manufacturing organizations (CMOs) producing kilogram to multi-kilogram quantities for client projects.

Basic Information

Product Name	5-(Trifluoromethyl)-1H-Indole-3-Carboxaldehyde
CAS No.	468718-16-3
Molecular Formula	C10H6F3NO
Molecular Weight	213.16 g/mol
Synonyms	5-(Trifluoromethyl)indole-3-carboxaldehyde; 5-Trifluoromethyl-1H-indole-3-carbaldehyde; 1H-Indole-3-carboxaldehyde, 5-(trifluoromethyl)-; 3-Formyl-5-(trifluoromethyl)indole; 5-(Trifluoromethyl)-1H-indole-3-carbaldehyde; 5-Trifluoromethylindole-3-carboxaldehyde; 5-CF3-Indole-3-carboxaldehyde; 5-(Trifluoromethyl)indole-3-carbaldehyde
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-1H-Indole-3-Carboxaldehyde is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA). The COA includes data for identity (IR, NMR), purity (HPLC), and specified impurity profiles, ensuring the material meets the stringent requirements for research and development as well as scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.