Description

2-(6-(Trifluoromethoxy)-1H-Indol-3-Yl)Ethanamine Hydrochloride is a high-purity, synthetically derived indole derivative, specifically a tryptamine hydrochloride salt, with the CAS registry number 467451-81-6. This compound is a critical pharmaceutical intermediate valued for its role in the synthesis of novel bioactive molecules, particularly in central nervous system (CNS) research. It is primarily required by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates targeting serotonin and related receptors.
• Neurological Research: Used in preclinical studies to investigate ligands for 5-HT (serotonin) receptor subtypes and other CNS targets.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of new chemical entities.
• Reference Standard: Employed as an analytical standard in quality control and method development for related pharmaceutical products.
• Biochemical Tool Compound: Utilized in vitro and in vivo to study signal transduction pathways and cellular responses.

Basic Information

Product Name	2-(6-(Trifluoromethoxy)-1H-Indol-3-Yl)Ethanamine Hydrochloride
CAS No.	467451-81-6
Molecular Formula	C11H12F3N2O • HCl
Molecular Weight	280.69 g/mol (Free base: 244.22 g/mol)
Synonyms	6-(Trifluoromethoxy)tryptamine hydrochloride; 2-(6-(Trifluoromethoxy)-1H-indol-3-yl)ethan-1-amine hydrochloride; 6-TFM-Tryptamine HCl; 1H-Indole-3-ethanamine, 6-(trifluoromethoxy)-, hydrochloride; α-Methyl-6-(trifluoromethoxy)-1H-indole-3-ethanamine hydrochloride; 5-(Trifluoromethoxy)tryptamine hydrochloride (common numbering variant); TFMT HCl
EINECS	Contact for details

Quality Control

Our 2-(6-(Trifluoromethoxy)-1H-Indol-3-Yl)Ethanamine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable for pharmaceutical intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.