Description

Methyl 3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Thiophene-2-Carboxylate is a high-value heterocyclic building block featuring both a maleimide and a thiophene moiety. This compound is critical for researchers and manufacturers developing advanced materials and pharmaceuticals, particularly through click chemistry and polymer conjugation reactions. It is primarily sought after by R&D teams in the pharmaceutical, agrochemical, and specialty polymer industries for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, especially those utilizing maleimide-thiol conjugation for antibody-drug conjugates (ADCs) and targeted therapies.
• Polymer Science & Functional Materials: Used as a monomer or cross-linking agent for creating specialty polymers with tailored properties, such as conductive polymers, photosensitive resins, and smart hydrogels.
• Bioconjugation & Probe Synthesis: Essential for labeling proteins, peptides, and other biomolecules due to its reactive maleimide group, which selectively bonds with thiols under mild conditions.
• Agrochemical Research: Employed in the development of new pesticides and herbicides, where the thiophene scaffold can impart specific biological activity.
• Organic Electronic Materials: Acts as a building block for π-conjugated systems used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Chemical Biology Tool: Utilized to create activity-based probes and affinity labels for studying enzyme function and protein interactions.

Basic Information

Product Name	Methyl 3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Thiophene-2-Carboxylate
CAS No.	465514-23-2
Molecular Formula	C10H7NO4S
Molecular Weight	237.23 g/mol
Synonyms	1-(5-(Methoxycarbonyl)thiophen-3-yl)-1H-pyrrole-2,5-dione; Methyl 3-maleimidothiophene-2-carboxylate; 3-Maleimidothiophene-2-carboxylic acid methyl ester; Thiophene-2-carboxylic acid, 3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, methyl ester; 1H-Pyrrole-2,5-dione, 1-[5-(methoxycarbonyl)-3-thienyl]-; Methyl 3-(maleimido)thiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Thiophene-2-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.