Description

tert-Butyl 8-Hydroxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, protected heterocyclic building block essential for advanced organic synthesis. This compound matters as a critical intermediate in the development of novel pharmaceutical agents, particularly in the synthesis of complex molecules targeting neurological and cardiovascular pathways. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of isoquinoline-based drug candidates, including potential kinase inhibitors and receptor modulators.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing combinatorial libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) under GMP-like conditions.
• Agrochemical Synthesis: Intermediate in the development of new herbicides and pesticides with novel modes of action.
• Academic & Institutional R&D: Employed in university and research institute laboratories for methodological studies and the synthesis of complex natural product analogs.
• Fine Chemical Production: Building block for specialty chemicals, dyes, and advanced materials requiring specific chiral or functionalized isoquinoline cores.

Basic Information

Product Name	tert-Butyl 8-Hydroxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	464900-21-8
Molecular Formula	C₁₄H₁₉NO₃
Molecular Weight	249.31 g/mol
Synonyms	8-Hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 8-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 2(1H)-Isoquinolinecarboxylic acid, 8-hydroxy-3,4-dihydro-, 1,1-dimethylethyl ester; Boc-8-OH-Tic-OH; 8-Hydroxy-Tic-OtBu; 464900-21-8; tert-Butyl 8-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Hydroxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.