Description

n-Acetyl Folic Acid-D4 is a high-purity, deuterium-labeled derivative of folic acid, specifically designed for use as an internal standard in advanced analytical techniques. This compound is critical for ensuring the accuracy and reliability of quantitative measurements in complex biological and pharmaceutical matrices. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, clinical diagnostics, and nutritional supplement industries who require precise and traceable analytical results.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable isotope-labeled internal standard for the precise quantification of folic acid and its metabolites in bioanalytical assays.
• Pharmaceutical R&D: Used in pharmacokinetic and pharmacodynamic studies to track drug metabolism and ensure accurate measurement of folate-based pharmaceuticals.
• Clinical Diagnostics: Enables accurate measurement of folate levels in serum, plasma, and whole blood for nutritional status assessment and disease research.
• Food & Nutritional Analysis: Critical for the accurate fortification analysis of folic acid in infant formula, dietary supplements, and fortified food products.
• Method Development & Validation: Serves as a key reference material for developing and validating robust, high-sensitivity analytical methods in regulated environments.
• Metabolomics Research: Facilitates the study of one-carbon metabolism pathways in cellular and biochemical research.

Basic Information

Product Name	n-Acetyl Folic Acid-D4
CAS No.	461426-36-8
Molecular Formula	C₂₀H₁₅D₄N₇O₆
Molecular Weight	465.42 g/mol
Synonyms	Deuterated N-Acetyl Folic Acid; N-Acetyl Folic Acid-d4; N-Acetylpteroylglutamic Acid-d4; Folic Acid-d4 N-Acetate; (2S)-2-[[4-[[(2-Amino-5,6,7,8-tetradeuterio-4-oxo-1H-pteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic Acid; Acetyl Folate-d4; Vitamin B9 Acetate-d4; pteroylmonoglutamic acid N-acetyl derivative-d4
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl Folic Acid-D4 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical purity and isotopic enrichment suitable for sensitive mass spectrometry applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity (by HPLC), isotopic purity (by MS), and other critical parameters to ensure compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric humidity. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.