Description

n-(4-Aminobenzoyl-D4)-L-Glutamic Acid is a high-purity, deuterated derivative of a key folate metabolite intermediate. This compound is specifically designed for use as an internal standard in advanced analytical techniques, ensuring precise and reliable quantification. It is an essential material for research and quality control laboratories in the pharmaceutical and life sciences sectors, particularly those focused on folate metabolism, drug development, and clinical diagnostics.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the accurate quantification of folate-related compounds and metabolites in complex biological matrices.
• Pharmaceutical R&D: Used in the research and development of novel therapeutics targeting folate pathways, including antifolate drugs and metabolic modulators.
• Clinical Diagnostics: Enables precise measurement of folate and its metabolites in patient samples for diagnostic and nutritional status assessment.
• Biochemical Research: Serves as a critical reagent in studies investigating folate metabolism, enzyme kinetics, and cellular one-carbon pathways.
• Method Development & Validation: Essential for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Metabolomics Studies: A valuable tool in targeted metabolomics to understand disease mechanisms and identify biomarkers related to folate and amino acid metabolism.

Basic Information

Product Name	n-(4-Aminobenzoyl-D4)-L-Glutamic Acid
CAS No.	461426-34-6
Molecular Formula	C₁₂H₁₀D₄N₂O₅
Molecular Weight	278.27 g/mol
Synonyms	4-Aminobenzoyl-D4-L-glutamic Acid; (2S)-2-[(4-Aminobenzoyl-D4)amino]pentanedioic acid; Deuterated p-Aminobenzoylglutamic Acid; PABG-D4; ABG-D4; Deutero-n-(4-Aminobenzoyl)-L-glutamic Acid; Internal Standard for Folate Analysis; L-Glutamic acid, N-[4-(amino-D4)benzoyl]-
EINECS	Contact for details

Quality Control

Every batch of n-(4-Aminobenzoyl-D4)-L-Glutamic Acid is manufactured and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, with comprehensive characterization using NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, isotopic purity (D-enrichment), and other critical parameters to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term stability, consider storage at 2-8°C. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.