Description

4-(Trifluoroacetylamino)Benzoic Acid-D4 is a high-purity, deuterated derivative of 4-(trifluoroacetylamino)benzoic acid, specifically designed for use as an internal standard in advanced analytical applications. This compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in mass spectrometry, where it compensates for matrix effects and instrument variability. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, agrochemical, and analytical chemistry sectors for method development and precise quantification.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the accurate quantification of its non-deuterated analog or related compounds in complex biological and environmental matrices.
• Pharmaceutical Metabolism Studies: Used in pharmacokinetic and drug metabolism research to track and quantify parent drugs and metabolites with high precision.
• Analytical Method Development: Essential for developing and validating robust, high-sensitivity analytical methods in compliance with regulatory guidelines (e.g., FDA, ICH).
• Isotope Dilution Mass Spectrometry (IDMS): Employed in this gold-standard technique for achieving the highest possible accuracy in quantitative analysis.
• Environmental Analysis: Facilitates the precise measurement of trace-level chemical pollutants or their degradation products in environmental samples.
• Biomarker Research: Enables reliable quantification of specific biomarkers in clinical and preclinical studies.

Basic Information

Product Name	4-(Trifluoroacetylamino)Benzoic Acid-D4
CAS No.	461426-32-4
Molecular Formula	C9H3D4F3NO3
Molecular Weight	234.16 g/mol
Synonyms	4-(Trifluoroacetamido)benzoic-2,3,5,6-d4 Acid; 4-(2,2,2-Trifluoroacetamido)benzoic-d4 Acid; Benzoic-2,3,5,6-d4 acid, 4-[(trifluoroacetyl)amino]-; p-(Trifluoroacetylamino)benzoic Acid-d4; Deuteronated 4-TFABA; TFABA-d4; Internal Standard for TFABA
EINECS	Contact for details

Quality Control

Every batch of 4-(Trifluoroacetylamino)Benzoic Acid-D4 is manufactured and tested under strict quality management systems to ensure exceptional isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm deuteration level and chemical purity, ensuring compliance with the stringent requirements for analytical internal standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuteration Degree)	≥98 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.