Description

5'-O-(4,4'-Dimethoxytrityl)-3-Formylindole-2'-Deoxyriboside is a sophisticated nucleoside derivative and a critical protected intermediate in the synthesis of modified oligonucleotides. Its value lies in enabling the precise incorporation of functionalized indole bases, which are essential for developing advanced probes, diagnostics, and therapeutic nucleic acids. This high-purity building block is primarily needed by research institutions and pharmaceutical companies engaged in antisense technology, aptamer development, and the creation of novel genetic tools.

Application

• Oligonucleotide Synthesis: Serves as a key phosphoramidite precursor for the solid-phase synthesis of DNA strands containing modified indole nucleobases.
• Antisense & siRNA Research: Used to create oligonucleotides with enhanced binding affinity or novel functionality for gene silencing applications.
• Aptamer Development: Enables the introduction of unique hydrophobic or stacking interactions within nucleic acid libraries for selecting high-affinity binders.
• Diagnostic Probe Fabrication: Incorporated into fluorescent or chemiluminescent probes (e.g., molecular beacons) to improve specificity and signal-to-noise ratios.
• Structural Biology Studies: Used to prepare oligonucleotides for X-ray crystallography or NMR to study DNA-protein interactions and nucleic acid structure.
• Therapeutic Nucleic Acid R&D: A vital raw material in the development of next-generation oligonucleotide-based therapeutics.

Basic Information

Product Name	5'-O-(4,4'-Dimethoxytrityl)-3-Formylindole-2'-Deoxyriboside
CAS No.	460355-04-8
Molecular Formula	C35H32N2O6
Molecular Weight	576.64 g/mol
Synonyms	5'-O-DMT-3-Formylindole-2'-deoxyriboside; 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl]-3-formyl-1H-indole; 3-Formylindole-2'-deoxyriboside 5'-O-(4,4'-dimethoxytrityl) ether; DMT-3-FI-dR; N3-Formyl-2'-deoxyriboside DMT-protected; 1-(5-O-(4,4'-Dimethoxytrityl)-2-deoxy-β-D-ribofuranosyl)-1H-indole-3-carboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 5'-O-(4,4'-Dimethoxytrityl)-3-Formylindole-2'-Deoxyriboside is manufactured and tested under strict quality management systems to ensure the high purity and consistency required for sensitive oligonucleotide synthesis. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing identity, purity (HPLC), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged manipulations. Keep container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.