Description

1-Iodo-2,3,4-Trifluorobenzene is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both iodine and fluorine substituents, makes it a versatile intermediate for creating complex molecules with tailored properties. This compound is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries for applications such as drug discovery and the development of specialty polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting central nervous system and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, improving electronic properties and device performance.
• Cross-Coupling Reactions: The iodine moiety acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct biaryl and other complex structures.
• Positron Emission Tomography (PET) Tracer Development: Utilized in radiochemistry for synthesizing fluorine-18 labeled tracers for medical imaging.
• Specialty Polymer Modification: Incorporated into polymer backbones to impart specific characteristics like chemical resistance, thermal stability, or altered solubility.

Basic Information

Product Name	1-Iodo-2,3,4-Trifluorobenzene
CAS No.	459424-72-7
Molecular Formula	C6H2F3I
Molecular Weight	289.98 g/mol
Synonyms	2,3,4-Trifluoroiodobenzene; 1,2,3-Trifluoro-4-iodobenzene; 2,3,4-Trifluoro-1-iodobenzene; Iodo-2,3,4-trifluorobenzene; 4-Iodo-1,2,3-trifluorobenzene; Benzene, 1-iodo-2,3,4-trifluoro-; 459424-72-7 (CAS)
EINECS	Contact for details

Quality Control

Our 1-Iodo-2,3,4-Trifluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.