Description

3-Iodo-5-Bromo-1H-Indazole-1-Carboxylic Acid tert-Butyl Ester is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in providing a protected indazole scaffold with two distinct halogen handles (iodo and bromo), enabling sequential and site-selective cross-coupling reactions for the construction of complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the discovery and optimization of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science: Serves as a building block for creating functional organic materials, such as ligands for catalysts or components in organic electronics.
• Chemical Biology: Employed in the design and synthesis of molecular probes and bio-conjugation reagents for studying biological systems.
• Medicinal Chemistry SAR Studies: The orthogonal reactivity of the iodine and bromine substituents allows for parallel synthesis and rapid exploration of structure-activity relationships.
• Custom Synthesis: A versatile starting material for contract research and manufacturing organizations (CROs/CMOs) to produce bespoke compounds for client projects.

Basic Information

Product Name	3-Iodo-5-Bromo-1H-Indazole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	459133-68-7
Molecular Formula	C₁₂H₁₂BrIN₂O₂
Molecular Weight	423.05 g/mol
Synonyms	tert-Butyl 3-iodo-5-bromo-1H-indazole-1-carboxylate; 1H-Indazole-1-carboxylic acid, 5-bromo-3-iodo-, 1,1-dimethylethyl ester; 5-Bromo-3-iodo-1H-indazole-1-carboxylic acid tert-butyl ester; 3-Iodo-5-bromo-indazole-1-carboxylic acid tert-butyl ester; 459133-68-7; tert-Butyl 5-bromo-3-iodoindazole-1-carboxylate
EINECS	Contact for details

Quality Control

Our 3-Iodo-5-Bromo-1H-Indazole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.