Description

2-(2-Chloro-Acetylamino)-4-(4-Chloro-Phenyl)-Thiophene-3-Carboxylic Acid Ethyl Ester is a high-purity, synthetically valuable organic intermediate characterized by its distinct thiophene core functionalized with chloro-acetylamino and chloro-phenyl substituents. This compound matters for its critical role as a versatile building block in the synthesis of complex, biologically active molecules, offering precise structural control for advanced research and development. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in the areas of kinase inhibitors and other small-molecule drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially those targeting specific enzyme pathways.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core scaffold for constructing potential APIs with modified pharmacological properties.
• Biochemical Research: Used in life science research to create molecular probes and tool compounds for studying biological mechanisms.
• Agrochemical Synthesis: Employed in the development of new crop protection agents and pesticides due to its heterocyclic structure.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic materials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and process development projects.

Basic Information

Item	Details
Product Name	2-(2-Chloro-Acetylamino)-4-(4-Chloro-Phenyl)-Thiophene-3-Carboxylic Acid Ethyl Ester
CAS No.	457621-54-4
Molecular Formula	C15H13Cl2NO3S
Molecular Weight	358.24 g/mol
Synonyms	Ethyl 2-[(2-chloroacetyl)amino]-4-(4-chlorophenyl)-3-thiophenecarboxylate; 2-(2-Chloroacetamido)-4-(4-chlorophenyl)thiophene-3-carboxylic acid ethyl ester; 4-(4-Chlorophenyl)-2-[(2-chloroacetyl)amino]-3-thiophenecarboxylic acid ethyl ester; 457621-54-4; AKOS BRN 0971; Thiophene-3-carboxylic acid, 2-[(2-chloroacetyl)amino]-4-(4-chlorophenyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our 2-(2-Chloro-Acetylamino)-4-(4-Chloro-Phenyl)-Thiophene-3-Carboxylic Acid Ethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request, providing full traceability and compliance data for your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.