Description

(4-Oxo-5,6,7,8-Tetrahydro-4H-Benzo[4,5]Thieno[2,3-D]Pyrimidin-3-Yl)-Acetic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in oncology and other disease areas. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Kinase Inhibitor Research: Serves as a core scaffold for the development of potent and selective kinase inhibitors, a major class of oncology therapeutics.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and pharmacokinetic properties.
• Contract Research & Development: Supplied to CROs and CDMOs for custom synthesis and process development projects.
• Academic Research: Utilized in university and institutional labs for biochemical and pharmacological studies of novel heterocyclic compounds.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for potential commercial API manufacturing.

Basic Information

Product Name	(4-Oxo-5,6,7,8-Tetrahydro-4H-Benzo[4,5]Thieno[2,3-D]Pyrimidin-3-Yl)-Acetic Acid Methyl Ester
CAS No.	450376-42-8
Molecular Formula	C15H14N2O3S
Molecular Weight	302.35 g/mol
Synonyms	Methyl (4-oxo-5,6,7,8-tetrahydro-4H-benzo[4,5]thieno[2,3-d]pyrimidin-3-yl)acetate; 3-(Carboxymethyl)-5,6,7,8-tetrahydro-4H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one methyl ester; Benzo[4,5]thieno[2,3-d]pyrimidine-3-acetic acid, 5,6,7,8-tetrahydro-4-oxo-, methyl ester; CAS 450376-42-8.
EINECS	Contact for details

Quality Control

Our production of (4-Oxo-5,6,7,8-Tetrahydro-4H-Benzo[4,5]Thieno[2,3-D]Pyrimidin-3-Yl)-Acetic Acid Methyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed under inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.