Description

2-Chloro-n-[5-(4-Fluoro-Benzyl)-Thiazol-2-Yl]-Acetamide is a high-purity, specialized organic intermediate of significant interest in advanced chemical synthesis. This compound matters for its role as a critical building block in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific thiazole and acetamide functionalities into target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly those targeting neurological disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiazole moiety.
• Chemical Biology Probe: Employed in academic and industrial research to study enzyme inhibition and protein-ligand interactions due to its specific molecular scaffold.
• Fine Chemical Synthesis: Acts as a versatile building block for creating complex heterocyclic compounds for material science and specialty chemical applications.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and CROs for custom synthesis projects and scale-up development under cGMP conditions.

Basic Information

Product Name	2-Chloro-n-[5-(4-Fluoro-Benzyl)-Thiazol-2-Yl]-Acetamide
CAS No.	450360-92-6
Molecular Formula	C12H10ClFN2OS
Molecular Weight	284.74 g/mol
Synonyms	2-Chloro-N-[5-[(4-fluorophenyl)methyl]-1,3-thiazol-2-yl]acetamide; N-(5-(4-Fluorobenzyl)thiazol-2-yl)-2-chloroacetamide; 2-Chloroacetamide, N-[5-[(4-fluorophenyl)methyl]-2-thiazolyl]-; Acetamide, 2-chloro-N-[5-[(4-fluorophenyl)methyl]-2-thiazolyl]-; 450360-92-6; 2-Chloro-N-(5-(4-fluorobenzyl)thiazol-2-yl)acetamide
EINECS	Contact for details

Quality Control

Our 2-Chloro-n-[5-(4-Fluoro-Benzyl)-Thiazol-2-Yl]-Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use under cGMP conditions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.