Description

2-(2-Chloro-Acetylamino)-6-Methyl-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It serves as a key building block for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new compounds with potential biological activity. The precise chemical architecture offers a versatile platform for further functionalization.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing specific receptor activity.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides, leveraging the benzo[b]thiophene core for bioactive molecule design.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex heterocyclic systems due to its reactive chloroacetamido and ester functional groups.
• Chemical Biology Probe Development: Serves as a scaffold for creating molecular probes to study enzyme function or protein-protein interactions in biological systems.
• Material Science Precursor: Potential use in the synthesis of organic semiconductors or advanced polymers with specific electronic properties.

Basic Information

Item	Details
Product Name	2-(2-Chloro-Acetylamino)-6-Methyl-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid Methyl Ester
CAS No.	448226-78-6
Molecular Formula	C15H18ClNO3S
Molecular Weight	327.82 g/mol
Synonyms	Methyl 2-[(2-chloroacetyl)amino]-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate; 2-(2-Chloroacetamido)-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid methyl ester; 6-Methyl-2-[(2-chloroacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid methyl ester; 448226-78-6; Tetrahydrobenzothiophene derivative
EINECS	Contact for details

Quality Control

Every batch of 2-(2-Chloro-Acetylamino)-6-Methyl-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.