Description

2-(2-Chloro-Acetylamino)-4,5-Dimethyl-Thiophene-3-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific thiophene-based molecular architecture. This compound is of critical importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily needed by manufacturers and R&D laboratories in the pharmaceutical, agrochemical, and fine chemical sectors seeking reliable, high-quality intermediates for complex organic synthesis.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, especially those targeting specific biological pathways.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its heterocyclic structure.
• Organic Synthesis Building Block: Employed in academic and industrial research for constructing complex thiophene-containing molecules.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and functional materials.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	2-(2-Chloro-Acetylamino)-4,5-Dimethyl-Thiophene-3-Carboxylic Acid Methyl Ester
CAS No.	448199-06-2
Molecular Formula	C12H14ClNO3S
Molecular Weight	287.76 g/mol
Synonyms	Methyl 2-[(2-chloroacetyl)amino]-4,5-dimethylthiophene-3-carboxylate; 2-(2-Chloroacetamido)-4,5-dimethylthiophene-3-carboxylic acid methyl ester; 4,5-Dimethyl-2-[(2-chloroacetyl)amino]thiophene-3-carboxylic acid methyl ester; 2-(Chloroacetylamino)-4,5-dimethyl-3-thiophenecarboxylic acid methyl ester; 448199-06-2; Methyl 2-(2-chloroacetamido)-4,5-dimethylthiophene-3-carboxylate
EINECS	Contact for details

Quality Control

Our 2-(2-Chloro-Acetylamino)-4,5-Dimethyl-Thiophene-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements for research or cGMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.