Description

Methyl 3-[5-Cyano-2,4-Dioxo-3,4-Dihydro-1(2H)-Pyrimidinyl]-2-Thiophenecarboxylate is a high-value heterocyclic building block and advanced pharmaceutical intermediate. This compound is critical for research and development in medicinal chemistry, particularly for the synthesis of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside analogs and antiviral/anticancer drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new molecular entities.
• Organic Synthesis: Serves as a versatile precursor for constructing complex fused heterocyclic systems containing pyrimidine and thiophene motifs.
• Biochemical Research: Potential use in developing enzyme inhibitors or probes targeting nucleotide-binding proteins.
• Custom Synthesis: Starting material for contract research organizations (CROs) and CDMOs producing specialized compounds for client projects.

Basic Information

Product Name	Methyl 3-[5-Cyano-2,4-Dioxo-3,4-Dihydro-1(2H)-Pyrimidinyl]-2-Thiophenecarboxylate
CAS No.	446276-11-5
Molecular Formula	C11H7N3O4S
Molecular Weight	277.26 g/mol
Synonyms	Methyl 3-(5-cyano-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-2-thiophenecarboxylate; 2-Thiophenecarboxylic acid, 3-(5-cyano-2,4-dioxo-1,2,3,4-tetrahydro-1-pyrimidinyl)-, methyl ester; 3-(5-Cyano-2,4-dioxo-1,2,3,4-tetrahydro-1-pyrimidinyl)-2-thiophenecarboxylic acid methyl ester; CAS 446276-11-5
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with typical purities suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Our quality management system supports the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.