Description

2-tert-Butyl 8A-Methyl (8As)-6-Oxo-1,2,3,4,6,7,8,8A-Octahydroisoquinoline-2,8A-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex, fused bicyclic structure. This compound is of significant value in organic synthesis, particularly for constructing intricate molecular frameworks found in active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, where it serves as a critical building block.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly those targeting the central nervous system.
• Organic Synthesis Research: Used in academic and industrial R&D for methodology development and the construction of novel heterocyclic compounds.
• Asymmetric Catalysis Substrate: Serves as a substrate for testing and developing new chiral catalysts and synthetic routes.
• Precursor for Alkaloid Analogues: Acts as a foundational structure for synthesizing analogues of natural isoquinoline alkaloids with potential bioactivity.

Basic Information

Product Name	2-tert-Butyl 8A-Methyl (8As)-6-Oxo-1,2,3,4,6,7,8,8A-Octahydroisoquinoline-2,8A-Dicarboxylate
CAS No.	445312-78-7
Molecular Formula	C17H25NO5
Molecular Weight	323.39 g/mol
Synonyms	(8aS)-2-(tert-Butoxycarbonyl)-8a-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydroisoquinoline-8a-carboxylic acid methyl ester; Methyl (8aS)-2-[(tert-butoxy)carbonyl]-8a-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydroisoquinoline-8a-carboxylate; 2-tert-Butoxycarbonyl-8a-methyl-6-oxo-decahydroisoquinoline-8a-carboxylic acid methyl ester; (8aS)-2-Boc-8a-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydroisoquinoline-8a-carboxylate methyl ester; Bicyclic Proline Derivative; Octahydroisoquinolinedione Derivative
EINECS	Contact for details

Quality Control

Our 2-tert-Butyl 8A-Methyl (8As)-6-Oxo-1,2,3,4,6,7,8,8A-Octahydroisoquinoline-2,8A-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.