Description

[4-(Difluoromethyl)Phenyl]Methanol, also known as 4-(Hydroxymethyl)Benzal Fluoride, is a high-value fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a reactive benzylic alcohol group and a difluoromethyl substituent, enabling precise molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries seeking to incorporate fluorine atoms to modulate the biological activity, metabolic stability, and physicochemical properties of target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluoromethyl group enhances efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs), improving dielectric anisotropy and thermal stability.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, lower dielectric constants, and unique surface properties.
• Organic Electronic Materials: Utilized in the synthesis of charge-transport materials or emissive layers for OLEDs and other electronic devices.
• Fluorine-18 Radiochemistry: Potential precursor for the synthesis of PET (Positron Emission Tomography) tracers in medical imaging.

Basic Information

Product Name	[4-(Difluoromethyl)Phenyl]Methanol / 4-(Hydroxymethyl)Benzal Fluoride
CAS No.	444915-77-9
Molecular Formula	C8H8F2O
Molecular Weight	158.15 g/mol
Synonyms	4-(Difluoromethyl)benzyl alcohol; (4-(Difluoromethyl)phenyl)methanol; alpha,α-Difluoro-p-tolylcarbinol; 4-(Hydroxymethyl)benzal fluoride; 1-[4-(Difluoromethyl)phenyl]methanol; p-(Difluoromethyl)benzyl alcohol; Benzenemethanol, 4-(difluoromethyl)-
EINECS	Contact for details

Quality Control

Our [4-(Difluoromethyl)Phenyl]Methanol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support cGMP standards for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.