Description

6,7-Difluoroisoquinolin-1(2H)-One is a high-value fluorinated isoquinolinone derivative, serving as a critical building block in advanced organic synthesis. Its unique difluoro-substituted heterocyclic structure makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Development: Used in the research and production of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science Research: Employed in the development of organic electronic materials, such as OLED (Organic Light-Emitting Diode) components and charge-transport materials.
• Ligand and Catalyst Synthesis: Acts as a precursor for creating novel nitrogen-containing ligands used in catalytic systems for fine chemical manufacturing.
• Fluorine Chemistry Studies: Serves as a model compound in academic and industrial research exploring the effects of difluoro substitution on heterocyclic chemistry and reactivity.

Basic Information

Product Name	6,7-Difluoroisoquinolin-1(2H)-One
CAS No.	444898-79-7
Molecular Formula	C9H5F2NO
Molecular Weight	181.14 g/mol
Synonyms	1H-Isoquinolin-1-one, 6,7-difluoro-; 6,7-Difluoro-1H-isoquinolin-1-one; 6,7-Difluoro-1,2-dihydroisoquinolin-1-one; 6,7-Difluoro-1-isoquinolinone; 6,7-Difluoro-1,2-dihydroisoquinolin-1-one; Difluoroisoquinolinone Building Block
EINECS	Contact for details

Quality Control

Our 6,7-Difluoroisoquinolin-1(2H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.