Description

(+/-)-Rac-2-(2-Chlorophenyl)-(6,7-Dihydro-4H-Thieno[3,2-C]Pyridin-5-Yl)Acetonitrile CAS NO 444728-11-4 is a high-purity, advanced pharmaceutical intermediate characterized by its unique thienopyridine scaffold. This compound is of significant commercial interest for its role as a key building block in the research and development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex heterocyclic molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Used in the development of complex heterocyclic compounds, leveraging its fused thiophene and pyridine rings.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and scale-up of proprietary molecules.
• Academic Research: Utilized in university and institutional labs for studying synthetic methodologies and new chemical entities.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	(+/-)-Rac-2-(2-Chlorophenyl)-(6,7-Dihydro-4H-Thieno[3,2-C]Pyridin-5-Yl)Acetonitrile
CAS No.	444728-11-4
Molecular Formula	C15H13ClN2S
Molecular Weight	288.79 g/mol
Synonyms	2-(2-Chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetonitrile (racemic); (±)-2-(2-Chlorophenyl)-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)acetonitrile; 5-(2-Chloro-α-cyanobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (racemate); Rac-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile; CAS 444728-11-4; Thieno[3,2-c]pyridine-5-acetonitrile, 2-(2-chlorophenyl)-6,7-dihydro- (racemic); 5-[(2-Chlorophenyl)(cyano)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine
EINECS	Contact for details

Quality Control

Our (+/-)-Rac-2-(2-Chlorophenyl)-(6,7-Dihydro-4H-Thieno[3,2-C]Pyridin-5-Yl)Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.