Description

tert-Butyl 4-(Isoquinolin-5-Yl)Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core linked to an isoquinoline moiety. This compound is valued for its role as a critical building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry research and development. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel therapeutics, including kinase inhibitors and other targeted agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, particularly in oncology and CNS research.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Kinase Inhibitor Synthesis: Used in the construction of potent and selective kinase inhibitors targeting various disease pathways.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological mechanisms and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) producing active pharmaceutical ingredients (APIs) on a commercial scale.
• Academic Research: Utilized in university and institutional labs for pioneering research in organic synthesis and drug discovery.

Basic Information

Product Name	tert-Butyl 4-(Isoquinolin-5-Yl)Piperazine-1-Carboxylate
CAS No.	444620-69-3
Molecular Formula	C18H23N3O2
Molecular Weight	313.40 g/mol
Synonyms	1-Boc-4-(isoquinolin-5-yl)piperazine; 5-(1-Boc-piperazin-4-yl)isoquinoline; tert-Butyl 4-(5-isoquinolyl)-1-piperazinecarboxylate; 1-Piperazinecarboxylic acid, 4-(5-isoquinolinyl)-, 1,1-dimethylethyl ester; Boc-4-(isoquinolin-5-yl)piperazine; 4-(Isoquinolin-5-yl)piperazine-1-carboxylic acid tert-butyl ester; 5-(4-Boc-piperazin-1-yl)isoquinoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Isoquinolin-5-Yl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.