Description

1-Boc-4-(1,2,3,4-Tetrahydroisoquinolin-8-Yl)Piperazine is a high-purity, advanced pharmaceutical intermediate and building block used in sophisticated organic synthesis. This compound is critical for research and development in medicinal chemistry, particularly for constructing complex molecular architectures. It is primarily utilized by pharmaceutical companies, biotechnology R&D labs, and fine chemical manufacturers focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology: Employed in the development of chemical probes and tool compounds for studying biological pathways and target validation.
• Fine Chemical Synthesis: Serves as a precursor for the preparation of more complex heterocyclic compounds and specialty chemicals.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	1-Boc-4-(1,2,3,4-Tetrahydroisoquinolin-8-Yl)Piperazine
CAS No.	444620-34-2
Molecular Formula	C18H27N3O2
Molecular Weight	317.43 g/mol
Synonyms	8-(4-Boc-piperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline; tert-Butyl 4-(1,2,3,4-tetrahydroisoquinolin-8-yl)piperazine-1-carboxylate; 1,2,3,4-Tetrahydro-8-(1-piperazinyl)isoquinoline 1-Boc derivative; 1-Boc-4-(8-isoquinolinyl)piperazine (tetrahydro); 1-(tert-Butoxycarbonyl)-4-(1,2,3,4-tetrahydro-8-isoquinolinyl)piperazine; BOC-THIQ-Piperazine; 444620-34-2
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(1,2,3,4-Tetrahydroisoquinolin-8-Yl)Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring the material is suitable for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.