Description

Thiophene-3-Ol, 4-Aminotetrahydro-, 1,1-Dioxide, (3S,4S)- (9Ci) is a high-purity, stereochemically defined sulfone derivative of aminotetrahydrothiophene, serving as a critical advanced pharmaceutical intermediate (API intermediate) and a versatile chiral building block in organic synthesis. Its value lies in its unique molecular architecture, which provides a rigid, functionalized scaffold for constructing complex molecules with high stereochemical fidelity. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise, high-quality intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Research: Used as a building block for developing new generation pesticides and herbicides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Employed in the design of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Chemical Biology Probes: Serves as a core structure for creating molecular probes to study enzyme function and biological pathways.
• Material Science Precursor: Potential use in the synthesis of functionalized polymers and advanced materials with specific electronic or structural properties.

Basic Information

Product Name	Thiophene-3-Ol, 4-Aminotetrahydro-, 1,1-Dioxide, (3S,4S)- (9Ci)
CAS No.	444608-38-2
Molecular Formula	C4H9NO3S
Molecular Weight	151.18 g/mol
Synonyms	(3S,4S)-4-Aminotetrahydrothiophene-3-ol 1,1-Dioxide; (3S,4S)-3-Hydroxy-4-aminotetrahydrothiophene 1,1-Dioxide; cis-4-Amino-3-hydroxytetrahydrothiophene 1,1-Dioxide; 4-Amino-3-hydroxytetrahydrothiophene-1,1-dioxide (cis-); Tetrahydro-4-amino-3-thiophenol 1,1-dioxide (stereospecific); 3-Thiophenemethanol, 4-aminohexahydro-, 1,1-dioxide, (3S,4S)-; Chiral sulfolane amino alcohol derivative
EINECS	Contact for details

Quality Control

Our production of Thiophene-3-Ol, 4-Aminotetrahydro-, 1,1-Dioxide, (3S,4S)- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment, supporting cGMP and ISO quality standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.