Description

D-2-Boc-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a trifluoromethyl-substituted tetrahydroisoquinoline scaffold. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates, especially those targeting protease enzymes and GPCRs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its privileged isoquinoline structure and metabolically stable trifluoromethyl group.
• Peptidomimetic Development: Serves as a constrained amino acid analog for constructing peptide-like molecules with enhanced bioavailability and stability.
• Chemical Biology Probes: Employed in the development of tool compounds and labeled ligands for target identification and validation studies.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.
• Academic Research: Used in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	D-2-Boc-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	444583-37-3
Molecular Formula	C₁₆H₁₈F₃NO₄
Molecular Weight	345.32 g/mol
Synonyms	(3R)-2-[(tert-Butoxy)carbonyl]-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; D-2-(tert-Butoxycarbonyl)-7-(trifluoromethyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic Acid; (R)-2-Boc-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Boc-D-7-CF3-Tic-OH; (R)-2-(tert-Butoxycarbonyl)-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; D-7-Trifluoromethyl-Tic(Boc)-OH
EINECS	Contact for details

Quality Control

Our D-2-Boc-7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support our clients' regulatory needs and can provide material with specifications tailored to GMP or ISO standards for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.