Description

(R)-3-Formyl-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is a high-value chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries where precise stereochemistry is required.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular research.
• Asymmetric Synthesis: Serves as a versatile precursor in catalytic asymmetric reactions to construct complex molecular architectures.
• API Development: Used in the research, development, and scale-up production of Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Fine Chemical Production: Employed in the manufacture of high-purity specialty chemicals and complex organic compounds.
• Agrochemical Research: Potential intermediate in the development of new chiral agrochemicals and plant protection agents.

Basic Information

Product Name	(R)-3-Formyl-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester
CAS No.	444583-19-1
Molecular Formula	C15H17NO3
Molecular Weight	259.30 g/mol
Synonyms	(R)-3-Formyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl (R)-3-formyl-3,4-dihydro-1H-isoquinoline-2-carboxylate; (R)-2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxaldehyde; Boc-(R)-3-Formyl-1,2,3,4-tetrahydroisoquinoline; (R)-N-Boc-3-formyl-1,2,3,4-tetrahydroisoquinoline; (R)-3-Formyl-N-Boc-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our (R)-3-Formyl-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure high chemical purity and chiral integrity, suitable for demanding synthetic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP guidelines where applicable to support pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.