Description

3-Pyridazinemethanol,Hexahydro-5-Hydroxy-,(3S,5S)-(9Ci) is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic interest. Its defined stereochemistry and functionalized pyridazine core make it a valuable scaffold for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific stereocenters and heterocyclic motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of potential drug candidates targeting central nervous system (CNS) disorders, infectious diseases, or metabolic conditions.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing compound libraries via parallel synthesis, enabling structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Used in catalytic asymmetric reactions to create enantiomerically pure compounds, leveraging its existing (3S,5S) stereocenters.
• Agrochemical Development: Employed in the research phase for creating novel herbicides, fungicides, or insecticides with specific biological activity.
• Ligand and Catalyst Design: The pyridazine methanol structure can be modified to create novel chelating ligands or organocatalysts for specialized chemical transformations.
• Academic Research: Used in universities and research institutes for methodological studies in heterocyclic chemistry and stereoselective synthesis.

Basic Information

Product Name	3-Pyridazinemethanol,Hexahydro-5-Hydroxy-,(3S,5S)-(9Ci)
CAS No.	443649-14-7
Molecular Formula	C5H10N2O2
Molecular Weight	130.15 g/mol
Synonyms	(3S,5S)-Hexahydro-5-hydroxy-3-pyridazinemethanol; (3S,5S)-5-Hydroxyhexahydro-3-pyridazinemethanol; (3S-cis)-Tetrahydro-5-hydroxy-3-pyridazinemethanol; (3S,5S)-1,2-Diazinane-3,5-diyldimethanol; A Chiral 1,2-Diazinane Diol Derivative; (3S,5S)-3,5-Bis(hydroxymethyl)piperidazine; Hexahydro-5-hydroxy-3-pyridazinemethanol (stereoisomer).
EINECS	Contact for details

Quality Control

Our 3-Pyridazinemethanol,Hexahydro-5-Hydroxy-,(3S,5S)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (3S,5S)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.