Description

2H-Indol-2-One, 1,3-Dihydro-5-Methyl-3-Methylene- (9Ci) is a specialized heterocyclic organic compound featuring a reactive methylidene group on its indolinone core. This unique molecular structure makes it a valuable and versatile chemical intermediate for advanced synthesis in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on novel active ingredients. The compound is supplied with a CAS Number of 442883-72-9, ensuring precise identification and traceability for global sourcing and regulatory compliance.

Application

This compound serves as a critical building block in sophisticated organic synthesis. Its primary applications include:

• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Acts as a precursor in the creation of new pesticides, herbicides, and plant growth regulators with enhanced efficacy.
• Material Science Research: Employed in the synthesis of advanced organic materials, including dyes, pigments, and functional polymers.
• Academic & Contract Research: A key reagent for methodological studies and complex molecule construction in university and CRO laboratory settings.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.

Basic Information

Product Name	2H-Indol-2-One, 1,3-Dihydro-5-Methyl-3-Methylene- (9Ci)
CAS No.	442883-72-9
Molecular Formula	C10H9NO
Molecular Weight	159.19 g/mol
Synonyms	5-Methyl-3-methylidene-1,3-dihydro-2H-indol-2-one; 3-Methylene-5-methyloxindole; 5-Methyl-3-methyleneindolin-2-one; 1,3-Dihydro-5-methyl-3-methylene-2H-indol-2-one; 442883-72-9; 5-Methyl-3-methylideneindolin-2-one; 3-Methylene-5-methyl-2-indolinone
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fine chemical intermediates. Each batch of 2H-Indol-2-One, 1,3-Dihydro-5-Methyl-3-Methylene- is analyzed using advanced techniques like HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. Our quality management system is designed to support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.