Description

1H-Indole-1-Carboxylic Acid, 5-(Bromomethyl)-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate designed for complex organic synthesis. This compound is valued for its reactive bromomethyl group and protected carboxylic acid functionality, enabling precise molecular construction. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex indole-based drug candidates, including potential kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of new herbicides and plant growth regulators that leverage the indole scaffold for biological activity.
• Chemical Synthesis: Serves as a versatile electrophile in cross-coupling reactions (e.g., Suzuki, Heck) and nucleophilic substitutions to introduce functionalized indole moieties.
• Material Science Precursor: Employed in the research of organic electronic materials and specialty polymers where the indole structure is integral.
• Bioconjugation & Probe Development: The reactive bromomethyl site allows for attachment to biomolecules or fluorescent tags for research tools and diagnostics.

Basic Information

Product Name	1H-Indole-1-Carboxylic Acid, 5-(Bromomethyl)-, 1,1-Dimethylethyl Ester
CAS No.	442685-53-2
Molecular Formula	C15H18BrNO2
Molecular Weight	324.21 g/mol
Synonyms	tert-Butyl 5-(bromomethyl)-1H-indole-1-carboxylate; 5-(Bromomethyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-5-(bromomethyl)indole; Boc-5-(bromomethyl)indole; 5-Bromomethyl-1-Boc-indole; 1-Boc-5-(bromomethyl)indole; 5-(Bromomethyl)-1H-indole-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Every batch of 1H-Indole-1-Carboxylic Acid, 5-(Bromomethyl)-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.