Description

3,6,9,12,15,18-Hexaoxanonadecane-1-Thiol is a specialized polyethylene glycol (PEG) derivative featuring a terminal thiol (-SH) functional group. This compound is highly valued for its role as a heterobifunctional linker, enabling the conjugation of biomolecules, polymers, and surfaces through thiol-reactive chemistries such as maleimide or iodoacetyl groups. It is essential for researchers and manufacturers in the fields of bioconjugation, nanotechnology, and advanced material science, where precise surface modification and controlled assembly are required.

Application

• Bioconjugation and Protein Modification: Used as a linker to attach peptides, antibodies, or other proteins to surfaces, nanoparticles, or other polymers via the reactive thiol group.
• Nanoparticle Functionalization: Key for creating stable, biocompatible gold or quantum dot nanoparticles by forming self-assembled monolayers (SAMs) through the thiol-gold interaction.
• Hydrogel and Polymer Network Formation: Serves as a crosslinking agent in the synthesis of PEG-based hydrogels for drug delivery systems and tissue engineering scaffolds.
• Surface Plasmon Resonance (SPR) and Biosensor Chips: Applied to modify sensor surfaces with a hydrophilic PEG spacer layer to reduce non-specific binding and enable specific biomolecule immobilization.
• Drug Delivery Systems: Facilitates the site-specific attachment of therapeutic payloads to carrier systems like liposomes or polymeric micelles.
• Chromatography Media: Used to functionalize solid supports for affinity chromatography columns.

Basic Information

Product Name	3,6,9,12,15,18-Hexaoxanonadecane-1-Thiol
CAS No.	441771-60-4
Molecular Formula	C13H28O6S
Molecular Weight	312.42 g/mol
Synonyms	HS-PEG6-OH; 19-Mercapto-3,6,9,12,15,18-hexaoxanonadecan-1-ol; α-Thiol-ω-hydroxy hexaethylene glycol; 2,5,8,11,14,17-Hexaoxa-20-thiahenicosane-1,21-diol; Thiol-PEG6-alcohol; 1-Mercapto-3,6,9,12,15,18-hexaoxanonadecane; PEG6 dithiol derivative; Heterobifunctional PEG, SH-PEG-OH
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and manufacturing. Each batch is characterized to confirm identity, purity, and functional integrity. Certificates of Analysis (COA) are available upon request, detailing key parameters such as assay, thiol content, and impurity profiles. We adhere to strict quality management protocols to ensure supply reliability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation of the thiol group. For long-term storage, desiccate to protect against moisture. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Thiol Content (Titration)	≥ 90% of theoretical
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.