Description

2-n-Boc-5-Formyl-3,4-Dihydro-1H-Isoquinoline is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a reactive aldehyde functional group. This compound is critical for the synthesis of complex bioactive molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily utilized by research institutions and pharmaceutical manufacturers developing novel therapeutic agents, especially in the fields of central nervous system (CNS) and oncology research.

Application

• Key Intermediate in Drug Discovery: Serves as a crucial building block for the synthesis of tetrahydroisoquinoline-based drug candidates and pharmacophores.
• Medicinal Chemistry Research: Used in the design and construction of compound libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Synthesis of Alkaloid Analogues: A versatile precursor for creating analogues of natural isoquinoline alkaloids with potential biological activity.
• Peptidomimetic Development: The formyl group enables further functionalization, making it valuable for creating peptidomimetics and constrained peptides.
• API (Active Pharmaceutical Ingredient) Synthesis: Employed in the multi-step synthesis of potential active ingredients targeting various disease pathways.
• Chemical Biology Probes: Useful for creating labeled or tagged chemical probes to study biological mechanisms and protein interactions.

Basic Information

Item	Details
Product Name	2-n-Boc-5-Formyl-3,4-Dihydro-1H-Isoquinoline
CAS No.	441065-33-4
Molecular Formula	C15H19NO3
Molecular Weight	261.32 g/mol
Synonyms	5-Formyl-2-[(2-methylpropan-2-yl)oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline; 2-(tert-Butoxycarbonyl)-5-formyl-1,2,3,4-tetrahydroisoquinoline; 2-Boc-5-formyl-1,2,3,4-tetrahydroisoquinoline; 2-N-Boc-5-formyl-1,2,3,4-tetrahydroisoquinoline; 5-Formyl-2-N-Boc-tetrahydroisoquinoline; tert-Butyl 5-formyl-3,4-dihydro-1H-isoquinoline-2(1H)-carboxylate; Boc-5-CHO-THIQ
EINECS	Contact for details

Quality Control

Our 2-n-Boc-5-Formyl-3,4-Dihydro-1H-Isoquinoline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.