Description

3-Phenyl-4-Trimethylsilanyl-5,6,7,8-Tetrahydro-Isoquinoline is a high-value, organosilicon-substituted isoquinoline derivative that serves as a critical synthetic intermediate. Its unique structure, featuring both a phenyl and a trimethylsilyl (TMS) protecting group, makes it indispensable for advanced organic synthesis, particularly in constructing complex nitrogen-containing heterocycles. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially those targeting neurological and oncological pathways.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require complex heterocyclic cores.
• Material Science Precursor: Serves as a monomer or precursor for advanced polymers and organic electronic materials due to its silicon functionality.
• Ligand Synthesis: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry, particularly in cross-coupling and C-H functionalization reactions.
• Fine Chemical Production: Intermediate in the multi-step synthesis of dyes, pigments, and other specialty chemicals.

Basic Information

Product Name	3-Phenyl-4-Trimethylsilanyl-5,6,7,8-Tetrahydro-Isoquinoline
CAS No.	440365-51-5
Molecular Formula	C20H27NSi
Molecular Weight	309.52 g/mol
Synonyms	4-(Trimethylsilyl)-3-phenyl-5,6,7,8-tetrahydroisoquinoline; 3-Phenyl-4-(trimethylsilyl)-5,6,7,8-tetrahydroisoquinoline; 5,6,7,8-Tetrahydro-3-phenyl-4-(trimethylsilyl)isoquinoline; 440365-51-5; TMS-Phenyl-THIQ
EINECS	Contact for details

Quality Control

Our 3-Phenyl-4-Trimethylsilanyl-5,6,7,8-Tetrahydro-Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.