Description

2-Bromothiazole-5-Carbonitrile is a versatile and high-value brominated heterocyclic building block essential for modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel thiazole-based derivatives.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, especially in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides that leverage the thiazole moiety for bioactivity.
• Material Science Precursor: Serves as a building block for functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probe Development: Employed in creating tagged molecules and activity-based probes for studying biological pathways.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Nucleophilic Substitution & Functionalization: The nitrile group provides a handle for further transformation into amides, acids, tetrazoles, and other functional groups.

Basic Information

Product Name	2-Bromothiazole-5-Carbonitrile
CAS No.	440100-94-7
Molecular Formula	C4HBrN2S
Molecular Weight	189.03 g/mol
Synonyms	5-Cyano-2-bromothiazole; 2-Bromo-5-cyanothiazole; 2-Bromothiazole-5-carbonitrile; Thiazole, 2-bromo-5-cyano-; 2-Bromo-1,3-thiazole-5-carbonitrile; Bromothiazolecarbonitrile
EINECS	Contact for details

Quality Control

Our 2-Bromothiazole-5-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.