Description

3-Hydroxy-5-Methyl-3-[2-Oxo-2-(Thiophen-2-Yl)Ethyl]-1,3-Dihydro-2H-Indol-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique indolinone-thiophene hybrid structure. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in research targeting central nervous system (CNS) and metabolic disorders. Pharmaceutical R&D teams and fine chemical manufacturers need this precise building block to develop new therapeutic candidates with enhanced efficacy and selectivity.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of novel drug candidates, especially for neurological and psychiatric applications.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Medicinal Chemistry Research: Provides a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Biochemical Research: Employed as a tool compound or ligand in biochemical assays to study specific enzyme or receptor interactions.
• Fine Chemical Production: Supplied to contract manufacturing organizations (CMOs) and CDMOs for scale-up under cGMP conditions.

Basic Information

Product Name	3-Hydroxy-5-Methyl-3-[2-Oxo-2-(Thiophen-2-Yl)Ethyl]-1,3-Dihydro-2H-Indol-2-One
CAS No.	439091-18-6
Molecular Formula	C₁₅H₁₃NO₃S
Molecular Weight	287.33 g/mol
Synonyms	3-Hydroxy-5-methyl-3-[2-oxo-2-(thiophen-2-yl)ethyl]indolin-2-one; 5-Methyl-3-hydroxy-3-[2-oxo-2-(2-thienyl)ethyl]-1,3-dihydro-2H-indol-2-one; 1,3-Dihydro-3-hydroxy-5-methyl-3-[2-oxo-2-(2-thienyl)ethyl]-2H-indol-2-one; 439091-18-6; Thiophene-substituted indolinone derivative
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-5-Methyl-3-[2-Oxo-2-(Thiophen-2-Yl)Ethyl]-1,3-Dihydro-2H-Indol-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.