Description

2-Ethyl 4-Isopropyl 5-Amino-3-Methylthiophene-2,4-Dicarboxylate is a high-purity, functionalized thiophene derivative serving as a critical advanced intermediate in organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific thiophene-based motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Serves as a precursor in the development of new-generation herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Used in the creation of organic semiconductors, conductive polymers, and non-linear optical (NLO) materials due to the electron-rich thiophene core.
• Dye and Pigment Industry: Intermediate for synthesizing specialized heterocyclic dyes and pigments with unique colorfastness and light-absorption properties.
• Ligand and Catalyst Development: The amino and ester functional groups make it a valuable starting point for creating novel chelating ligands and organocatalysts.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific custom synthesis projects.

Basic Information

Product Name	2-Ethyl 4-Isopropyl 5-Amino-3-Methylthiophene-2,4-Dicarboxylate
CAS No.	438532-52-6
Molecular Formula	C14H21NO4S
Molecular Weight	299.39 g/mol
Synonyms	5-Amino-3-methylthiophene-2,4-dicarboxylic acid 2-ethyl 4-(1-methylethyl) ester; Ethyl isopropyl 5-amino-3-methylthiophene-2,4-dicarboxylate; 2,4-Dicarbethoxy-5-amino-3-methylthiophene (substituted); AI3-52362; 5-Amino-3-methyl-2,4-thiophenedicarboxylic Acid Diethyl Ester (isopropyl variant); Thiophene-2,4-dicarboxylate derivative; SCHEMBL21806217; BDBM50489357
EINECS	Contact for details

Quality Control

Every batch of 2-Ethyl 4-Isopropyl 5-Amino-3-Methylthiophene-2,4-Dicarboxylate is manufactured and tested under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for use in cGMP (current Good Manufacturing Practice) environments and advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.