Description

Isopropyl 2-Amino-4-(4-Isobutylphenyl)-5-Methylthiophene-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry. It is primarily sought by research institutions and manufacturers in the global pharmaceutical and fine chemical industries for developing new drug candidates and scaling up production processes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug molecules, especially those targeting inflammation and pain.
• API Development: Serves as a core scaffold for research and development of new Active Pharmaceutical Ingredients with potential therapeutic applications.
• Fine Chemical Synthesis: Used in multi-step organic synthesis to construct complex molecular architectures in laboratory and pilot-scale production.
• Biochemical Research: Employed in academic and industrial R&D for studying structure-activity relationships (SAR) and biological pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	Isopropyl 2-Amino-4-(4-Isobutylphenyl)-5-Methylthiophene-3-Carboxylate
CAS No.	438197-25-2
Molecular Formula	C19H25NO2S
Molecular Weight	331.47 g/mol
Synonyms	2-Amino-4-(4-isobutylphenyl)-5-methylthiophene-3-carboxylic acid isopropyl ester; Isopropyl 2-amino-4-(4-isobutylphenyl)-5-methyl-3-thiophenecarboxylate; 438197-25-2; 5-Methyl-2-amino-4-(4-isobutylphenyl)thiophene-3-carboxylic acid isopropyl ester; 3-Thiophenecarboxylic acid, 2-amino-4-[4-(2-methylpropyl)phenyl]-5-methyl-, 1-methylethyl ester
EINECS	Contact for details

Quality Control

Our Isopropyl 2-Amino-4-(4-Isobutylphenyl)-5-Methylthiophene-3-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC purity data, identity confirmation (IR, NMR), and impurity profiles. Our quality commitment aligns with ICH guidelines, and we support development under cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.