Description

2-[(Chloroacetyl)Amino]-6-Methyl-4,5,6,7-Tetrahydro-1-Benzothiophene-3-Carboxamide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop new drug candidates, leveraging its unique fused-ring system for targeted biological activity.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially in central nervous system (CNS) and metabolic disorder research.
• Active Pharmaceutical Ingredient (API) Development: Used as a core scaffold for developing new APIs with potential analgesic, anti-inflammatory, or neuroprotective properties.
• Medicinal Chemistry Research: A valuable building block for constructing complex heterocyclic libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Contract Research and Manufacturing (CRAM): Supplied to CDMOs for use in custom synthesis projects and process development for clinical trial materials.
• Bioconjugation and Probe Synthesis: The reactive chloroacetyl and carboxamide groups make it suitable for creating chemical probes or targeted conjugates for biochemical research.

Basic Information

Product Name	2-[(Chloroacetyl)Amino]-6-Methyl-4,5,6,7-Tetrahydro-1-Benzothiophene-3-Carboxamide
CAS No.	436090-09-4
Molecular Formula	C13H17ClN2O2S
Molecular Weight	300.80 g/mol
Synonyms	2-[(2-Chloroacetamido)]-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide; 6-Methyl-2-[(chloroacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide; 2-(Chloroacetylamino)-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide; Tetrahydrobenzothiophene-3-carboxamide derivative; CAS 436090-09-4
EINECS	Contact for details

Quality Control

Our production of 2-[(Chloroacetyl)Amino]-6-Methyl-4,5,6,7-Tetrahydro-1-Benzothiophene-3-Carboxamide adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and manufacturing applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting compliance in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.