Description

3-Amino-5-Fluoro-1H-Indole-2-Carboxylic Acid Methyl Ester is a high-value, multi-functional indole derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both amino and fluoro substituents, makes it an essential intermediate for creating complex molecules with targeted biological activity. This compound is primarily sought by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Organic Synthesis Building Block: Employed in complex multi-step syntheses to construct indole-based scaffolds for material science and chemical biology.
• Biochemical Probe Development: Serves as a starting material for creating fluorescent tags or molecular probes for diagnostic and research applications.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and discovery chemistry projects.

Basic Information

Product Name	3-Amino-5-Fluoro-1H-Indole-2-Carboxylic Acid Methyl Ester
CAS No.	436088-83-4
Molecular Formula	C10H9FN2O2
Molecular Weight	208.19 g/mol
Synonyms	Methyl 3-Amino-5-fluoro-1H-indole-2-carboxylate; 5-Fluoro-3-aminoindole-2-carboxylic acid methyl ester; 3-Amino-5-fluoroindole-2-carboxylic acid methyl ester; 1H-Indole-2-carboxylic acid, 3-amino-5-fluoro-, methyl ester; 436088-83-4; Methyl 3-amino-5-fluoroindole-2-carboxylate; 5-Fluoro-3-amino-1H-indole-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 3-Amino-5-Fluoro-1H-Indole-2-Carboxylic Acid Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. All materials are characterized by modern analytical techniques including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.