Description

1-Chloro-4-Fluoroisoquinoline is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique molecular scaffold, featuring both halogen and fluorine substituents, makes it a critical intermediate for constructing complex pharmacologically active molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Development: Used to create advanced active ingredients for crop protection products, including herbicides and fungicides.
• Material Science Research: Serves as a building block for developing organic electronic materials, such as OLEDs and semiconductors.
• Fluorinated Compound Synthesis: The fluorine atom provides a handle for further functionalization, enabling the creation of diverse fluorinated chemical libraries.
• Cross-Coupling Reactions: The chlorine substituent is an excellent leaving group for palladium-catalyzed reactions like Suzuki, Buchwald-Hartwig, and Negishi couplings.
• Ligand and Catalyst Design: The isoquinoline core can be modified to create novel ligands for metal catalysis.

Basic Information

Product Name	1-Chloro-4-Fluoroisoquinoline
CAS No.	435278-06-1
Molecular Formula	C9H5ClFN
Molecular Weight	181.59 g/mol
Synonyms	4-Fluoro-1-chloroisoquinoline; 1-Chloro-4-fluoroisoquinoline; Isoquinoline, 1-chloro-4-fluoro-; 435278-06-1; 1-Chloro-4-fluoro-isoquinoline; 4-Fluoro-1-chloro-isoquinoline; 1-Chloro-4-fluoro-1-isoquinoline
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-Fluoroisoquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to verify identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP and ISO 9001 compliant production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.