Description

1-Chloro-5-(Trifluoromethyl)-Isoquinoline is a high-value, multi-functional heterocyclic building block distinguished by its unique halogenated and fluorinated structure. This compound is critical for facilitating complex molecular transformations in advanced chemical synthesis, offering precise reactivity for constructing sophisticated target molecules. It is primarily sought after by research institutions and pharmaceutical developers engaged in medicinal chemistry, agrochemical discovery, and the creation of novel materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and oncology applications.
• Agrochemical Synthesis: Serves as a versatile precursor for developing advanced herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Used in the synthesis of organic electronic materials, such as ligands for OLEDs and charge-transport materials, due to its electron-deficient isoquinoline core.
• Cross-Coupling Reactions: The chlorine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig aminations.
• Fluorine Chemistry Building Block: The trifluoromethyl group provides a metabolically stable and lipophilic moiety, making it valuable for structure-activity relationship (SAR) studies in drug design.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Chloro-5-(Trifluoromethyl)-Isoquinoline
CAS No.	435278-04-9
Molecular Formula	C10H5ClF3N
Molecular Weight	231.60 g/mol
Synonyms	1-Chloro-5-(trifluoromethyl)isoquinoline; 5-(Trifluoromethyl)-1-chloroisoquinoline; Isoquinoline, 1-chloro-5-(trifluoromethyl)-; 1-Chloro-5-trifluoromethylisoquinoline; 435278-04-9; 1-Chloro-5-(trifluoromethyl)isoquinoline (CAS 435278-04-9)
EINECS	Contact for details

Quality Control

Our 1-Chloro-5-(Trifluoromethyl)-Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to supply chain integrity and traceability ensures reliable material for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.