Description

(3-([(tert-Butoxycarbonyl)Amino]Methyl)Pyridin-4-Yl)Boronic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a reactive boronic acid group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical companies for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Suzuki-Miyaura Cross-Coupling: Serves as a boronic acid coupling partner for the formation of carbon-carbon bonds in complex organic molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new therapeutic agents.
• Protease & Kinase Inhibitor Development: Integral to constructing heterocyclic scaffolds common in inhibitors targeting specific enzymes.
• Chemical Biology Probes: Employed in the creation of tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	(3-([(tert-Butoxycarbonyl)Amino]Methyl)Pyridin-4-Yl)Boronic Acid
CAS No.	433969-29-0
Molecular Formula	C12H19BN2O4
Molecular Weight	266.11 g/mol
Synonyms	4-Pyridineboronic acid, 3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-; BOC-Aminomethyl-4-pyridylboronic acid; tert-Butyl N-[(4-boranylpyridin-3-yl)methyl]carbamate; (3-((Boc-amino)methyl)pyridin-4-yl)boronic acid; N-Boc-3-(aminomethyl)-4-pyridineboronic acid; 3-(Boc-aminomethyl)-4-pyridylboronic acid; 4-Borono-3-((tert-butoxycarbonylamino)methyl)pyridine
EINECS	Contact for details

Quality Control

Our (3-([(tert-Butoxycarbonyl)Amino]Methyl)Pyridin-4-Yl)Boronic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material produced under ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.