Description

4-Bromo-4',4''-Dimethoxytrityl Alcohol is a specialized trityl-protected alcohol derivative, a key intermediate in synthetic organic chemistry. Its primary value lies in its role as a versatile protecting group reagent, particularly for the selective protection of hydroxyl groups during complex multi-step syntheses. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and oligonucleotide synthesis industries, where precise molecular assembly is critical.

Application

• Oligonucleotide and Peptide Synthesis: Serves as a crucial protecting group for the 5'-hydroxyl function in phosphoramidite-based solid-phase synthesis of DNA/RNA fragments.
• Pharmaceutical Intermediate: Used in the multi-step synthesis of active pharmaceutical ingredients (APIs) requiring selective protection and deprotection strategies.
• Agrochemical Development: Acts as a building block in the synthesis of complex molecules for advanced crop protection agents.
• Material Science Research: Employed in the development of novel polymers and dendrimers with specific functional group architectures.
• Academic & R&D Laboratories: A valuable reagent for methodological development in synthetic organic chemistry and catalysis studies.
• Fine Chemical Production: Utilized in the custom synthesis of high-value, low-volume specialty chemicals for various industrial applications.

Basic Information

Product Name	4-Bromo-4',4''-Dimethoxytrityl Alcohol
CAS No.	431039-52-0
Molecular Formula	C23H21BrO3
Molecular Weight	425.32 g/mol
Synonyms	4-Bromo-DMT-OH; 4-Bromo-4',4''-dimethoxytrityl alcohol; 4-Bromo-DMTr-OH; (4-Bromophenyl)bis(4-methoxyphenyl)methanol; 4-Bromo-DMT Alcohol; 4-Bromo-MMTr Alcohol; 4-Bromo-4',4''-dimethoxytriphenylmethanol; 4-Bromo-DMTr Alcohol
EINECS	Contact for details

Quality Control

Our 4-Bromo-4',4''-Dimethoxytrityl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR), to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.