Description

2-Thia-5-Azabicyclo[2.2.1]Heptan-3-One,5-Methyl-,(1S,4S)-(9Ci) is a high-purity, stereochemically defined bicyclic lactam building block of significant interest in advanced organic synthesis. This compound matters as a key chiral intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and other therapeutic areas requiring constrained, heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in neuroscience and antiviral research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce conformational rigidity and specific stereochemistry.
• Process Chemistry: Serves as a starting material or advanced intermediate in the development of scalable, cost-effective routes to target molecules.
• Asymmetric Synthesis: Exploited as a building block for constructing complex, enantiomerically pure natural product analogs and bioactive compounds.
• Chemical Biology: Utilized in the design and synthesis of molecular probes and tool compounds for studying biological pathways.
• Academic Research: Employed in methodological development and the exploration of new chemical spaces in synthetic organic chemistry.

Basic Information

Product Name	2-Thia-5-Azabicyclo[2.2.1]Heptan-3-One,5-Methyl-,(1S,4S)-(9Ci)
CAS No.	429675-63-8
Molecular Formula	C6H9NOS
Molecular Weight	143.21 g/mol
Synonyms	(1S,4S)-5-Methyl-2-thia-5-azabicyclo[2.2.1]heptan-3-one; (1S,4S)-5-Methyl-2-thia-5-azabicyclo[2.2.1]heptan-3-one (9CI); 5-Methyl-2-thia-5-azabicyclo[2.2.1]heptan-3-one, (1S,4S)-; (1S,4S)-5-Methyl-3-oxo-2-thia-5-azabicyclo[2.2.1]heptane; Bicyclic Lactam Sulfur Heterocycle; Chiral Thia-azabicycloheptanone
EINECS	Contact for details

Quality Control

Our 2-Thia-5-Azabicyclo[2.2.1]Heptan-3-One,5-Methyl-,(1S,4S)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding research and development applications. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccant packs in secondary containers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.