Description

3-Methoxy-5-(Trifluoromethyl)Thiophene-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block characterized by its thiophene core, methoxy substituent, and trifluoromethyl group. This compound matters for its unique reactivity profile, offering a versatile scaffold for synthesizing complex molecules with tailored electronic and steric properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by manufacturers of advanced materials and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of conductive polymers, organic semiconductors, and liquid crystals for electronic applications.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, esterifications, and amide bond formations to introduce the thiophene-carboxylic acid moiety into more complex molecular architectures.
• Chemical Research & Development: Essential for academic and industrial research exploring new reaction methodologies and the properties of fluorinated heterocyclic compounds.

Basic Information

Product Name	3-Methoxy-5-(Trifluoromethyl)Thiophene-2-Carboxylic Acid
CAS No.	425426-80-8
Molecular Formula	C7H5F3O3S
Molecular Weight	226.17 g/mol
Synonyms	2-Thiophenecarboxylic acid, 3-methoxy-5-(trifluoromethyl)-; 3-Methoxy-5-trifluoromethylthiophene-2-carboxylic acid; 5-(Trifluoromethyl)-3-methoxythiophene-2-carboxylic acid; 3-Methoxy-α,α,α-trifluoro-5-thiopheneacetic acid (related); 2-Carboxy-3-methoxy-5-trifluoromethylthiophene; 425426-80-8; 3-Methoxy-5-(trifluoromethyl)-2-thiophenecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of 3-Methoxy-5-(Trifluoromethyl)Thiophene-2-Carboxylic Acid adheres to stringent in-process controls and final batch release testing. Every lot is analyzed to ensure high chemical purity and consistency, meeting the exacting standards required for advanced synthetic applications. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.